PDRN Skin Treatment in NYC. The Salmon DNA Facial, Done Properly.
From $85060 minDowntime 1 to 2 days
A PDRN skin treatment in NYC is what the internet calls the salmon DNA facial. PDRN, short for polydeoxyribonucleotide, is a repair signal derived from salmon DNA. Fine needles create controlled micro channels so the skin rebuilds its own collagen, and the PDRN is applied to the skin as they open. It is not injected here. At Club 116 on Central Park South, 60 minutes, from $850.
Medically reviewed · September 2026
Microneedling With PDRN Before and After. What It Can Look Like.
One case, labeled the way the work is priced: the treatment, the count or the sessions, and how long after. This one is judged at four months, photographed in the same light and at the same distance, with no retouching.
A placeholder for layout, made to show how consented client photographs will appear. It shows no patient and no result. Real cases replace it as clients consent, photographed in the same light and at the same distance, with no retouching. Individual results vary.
Every caseWhat PDRN Does for Redness and Repair.
PDRN (polydeoxyribonucleotide) is a purified fragment of DNA derived from salmon that activates receptors in the skin which reduce inflammation and promote tissue repair. Applied to the skin during microneedling, it is used for redness, reactive skin, post acne marks and slow healing. It is not injected in the United States. At Club 116 in Manhattan it costs from $850 and takes 60 minutes.
Think of PDRN as the gentler cousin of Rejuran. Both are polynucleotides from salmon. PDRN is a smaller, simpler fragment with a particular strength in calming inflammation, which is why we reach for it when the skin needs resurfacing but tends to flare. The needles do the collagen work. The PDRN, applied pass by pass as the channels open, shortens healing time and keeps the reaction quieter. The result is skin that is calmer after each session, not just better at the end of the course.
Who it is for
Rosacea prone or reactive skin that still wants resurfacing, post acne redness, and skin recovering from a hard year of sun or stress. Anyone who found plain microneedling left them red for longer than they liked. Every skin tone.
Why do it here
The booster is chosen for your skin rather than from a package. A doctor signs off on anything applied to open channels, and a licensed clinician performs the treatment. The course is photographed under the same light at each visit. Nobody works on commission, so if your skin is too inflamed to needle at all, we suggest the Exoblank booster or LED instead.
Before, During and After.
Your skin is assessed under proper light and photographed, with particular attention to redness and any active flare. We ask about fish allergies and blood thinners. Numbing cream goes on for twenty to thirty minutes. No consultation fee, and the exact price is confirmed in writing first.
Fine needles pass over the face at controlled depths, kept lighter over reactive areas. The PDRN is applied to the skin as the channels open, pass by pass, and a final layer is left to absorb. It feels like fine sandpaper, warm and scratchy rather than painful.
Pink for a day, sometimes two, usually less than with plain needling, then a few days of dryness. Makeup after twenty four hours. Most people work the same afternoon.
Less redness after each session than plain needling. Calmer, more even skin builds across a course of three, spaced four to six weeks apart, and the collagen keeps maturing afterwards.
Read This Before You Book.
Downtime and aftercare
One to two days of pinkness and a dry, tight feel. Leave the booster on for the first few hours and do not wash the face until the next morning. Then sunscreen, a bland moisturizer, and nothing active (no retinol, acids or vitamin C) for five days. No makeup for the first day. No sweat, sauna or swimming for two days. Reactive skin should avoid heat and alcohol for a day longer.
Not for you if
You are pregnant, have active acne, eczema or a cold sore in the area, keloid scarring, a bleeding disorder, or take a blood thinner. Not if you have used isotretinoin in the last six months, or have a known allergy to fish or salmon products. Boosters applied to the skin are not used in pregnancy.
Members
Members pay $680, 20% off list, and the first signature facial is included when you join.
Individual results vary
Nothing on this page is a guarantee of an outcome or a substitute for the consultation. Suitability is confirmed by a clinician before anything is booked, and consent is taken in writing.
PDRN Skin Treatment in NYC: Questions People Ask First.
How much does a PDRN skin treatment cost in NYC?
At Club 116 on Central Park South, microneedling with PDRN is $850 a session, and $680 for members. That includes the numbing, the needling and the booster. There is no consultation fee, and the exact figure is in writing before anything starts.
How many PDRN sessions do I need, and how long does it last?
Three sessions, four to six weeks apart, is the usual course. Redness settles session by session, and the collagen change builds over the course. Most people maintain with a session every six to twelve months.
Is the salmon DNA facial injected?
Not here. In the United States PDRN is applied to the skin after microneedling, which is how it is used at Club 116. The injectable salmon DNA products sold abroad are not FDA approved and we do not inject them. The needles carry it to where it works; nothing goes into a syringe.
Which booster should I choose: PDRN, Rejuran, PRF or exosomes?
PDRN is the choice for reactive, rosacea prone or post acne red skin that still wants resurfacing. Rejuran is its stronger cousin for thin, crepey, sun weathered skin, at $900. PRF is what we suggest for most people doing a course for texture and scarring. Exosomes give the shortest recovery. The clinician recommends at the consult, and the booster can change between sessions.
Does PDRN microneedling hurt?
The needling is what you feel, not the booster. Numbing cream takes most of it, and people describe a warm, scratchy feeling like fine sandpaper. We keep the depth lighter over reactive areas.
Can I have PDRN microneedling if I have rosacea?
Often, yes, if the rosacea is not in an active flare. It is one of the boosters we reach for on rosacea prone skin because it calms inflammation while the needles do their work. During a flare we wait, or use the Exoblank exosome booster without needles instead. The clinician decides at the consult.
Often Booked Alongside.
PDRN Skin Treatment in NYC, from $850
For skin that wants resurfacing but tends to flare. Applied to the skin, not injected, and explained honestly before you pay. The exact figure is in writing before anything starts.
No consultation fee·No deposit to book·Exact price in writing before anything starts